Coverart for item
The Resource Proteopathic seeds and neurodegenerative diseases, Mathias Jucker, Yves Christen, editors, (electronic resource)

Proteopathic seeds and neurodegenerative diseases, Mathias Jucker, Yves Christen, editors, (electronic resource)

Label
Proteopathic seeds and neurodegenerative diseases
Title
Proteopathic seeds and neurodegenerative diseases
Statement of responsibility
Mathias Jucker, Yves Christen, editors
Contributor
Subject
Language
eng
Summary
The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans, and appears to occur many years before the onset of clinical symptoms. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer's disease, has increasingly implicated corruptive protein templating, or seeding, as a prime factor in the neurodegenerative process. The prion-like corruption of proteins also characterizes such clinically and etiologically diverse neurological disorders as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of affected proteins thus could reveal universal principles and common therapeutic targets for some of the most devastating and intractable human brain disorders
Member of
Dewey number
572/.6
Index
index present
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • Jucker, M.
  • Christen, Yves
Series statement
Research and perspectives in Alzheimer's disease,
http://library.link/vocab/subjectName
  • Prions
  • Neurodegenerative Diseases
  • Prions
  • Nervous system
Label
Proteopathic seeds and neurodegenerative diseases, Mathias Jucker, Yves Christen, editors, (electronic resource)
Instantiates
Publication
Note
Includes index
Antecedent source
unknown
Color
multicolored
Control code
ocn837287212
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9783642354915
Isbn Type
(electronic bk.)
Level of compression
unknown
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)837287212
Label
Proteopathic seeds and neurodegenerative diseases, Mathias Jucker, Yves Christen, editors, (electronic resource)
Publication
Note
Includes index
Antecedent source
unknown
Color
multicolored
Control code
ocn837287212
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9783642354915
Isbn Type
(electronic bk.)
Level of compression
unknown
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)837287212

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