Coverart for item
The Resource Prions and diseases., Volume 1, Physiology and pathophysiology, edited by Wen-Quan Zou and Pierluigi Gambetti, (electronic resource /)

Prions and diseases., Volume 1, Physiology and pathophysiology, edited by Wen-Quan Zou and Pierluigi Gambetti, (electronic resource /)

Label
Prions and diseases., Volume 1, Physiology and pathophysiology
Title
Prions and diseases.
Title number
Volume 1
Title part
Physiology and pathophysiology
Statement of responsibility
edited by Wen-Quan Zou and Pierluigi Gambetti
Title variation
Physiology and pathophysiology
Contributor
Subject
Language
eng
Summary
Transmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named prion or scrapie PrP (PrPSc), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases.Volume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer's disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume covers history from the high Middle Ages to the TSE era of Daniel Carleton Gajdusek, followed by the prion era of Stanley Prusiner whose extraordinary discovery opened a new chapter in prion research. Volume I will take you through the fascinating chronicle of prions in mammals, yeast, and fungi
Dewey number
579.29
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • Zou, Wen-Quan
  • Gambetti, Pierluigi
Series statement
Prions and diseases
Series volume
1
http://library.link/vocab/subjectName
  • Prions
  • Prion diseases
Label
Prions and diseases., Volume 1, Physiology and pathophysiology, edited by Wen-Quan Zou and Pierluigi Gambetti, (electronic resource /)
Instantiates
Publication
Antecedent source
unknown
Color
multicolored
Contents
  • Insoluble Cellular Prion Protein
  • Wen-Quan Zou
  • Protein Misfolding Cyclic Amplification
  • Fabio Moda, Sandra Pritzkow, Claudio Soto
  • Cofactor Involvement in Prion Propagation
  • Surachai Supattapone, Michael B. Miller
  • Prion Protein Conversion and Lipids
  • Jiyan Ma
  • New Perspectives on Prion Conversion: Introducing a Mechanism of Deformed Templating
  • Ilia V. Baskakov
  • Transmissible Spongiform Encephalopathy: From its Beginnings to Daniel Carlton Gajdusek
  • Infectious and Pathogenic Forms of PrP
  • Emiliano Biasini, David A. Harris
  • Cellular Mechanisms of Propagation and Clearance
  • Hermann M. Schatzl
  • Molecular Mechanisms Encoding Quantitative and Qualitative Traits of Prion Strains
  • Jiri G. Safar
  • Modeling the Cell Biology of Prions
  • Richard Rubenstein, Robert B. Petersen
  • Prion Strain Interference
  • Charles R. Schutt, Ronald A. Shikiya, Jason C. Bartz
  • Paul Brown
  • Introduction to Yeast and Fungal Prions
  • Reed B. Wickner
  • Yeast Prions Are Pathogenic, In-Register Parallel Amyloids
  • Reed B. Wickner, Herman K. Edskes, David A. Bateman
  • The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein
  • Glenn L. Millhauser
  • Role of Cellular Prion Protein in the Amyloid-[beta] Oligomer Pathophysiology of Alzheimer's Disease
  • Adam C. Kaufman, Stephen M. Strittmatter
  • Cellular Prion Protein and Cancers
  • Wei Xin, Man-sun Sy, Chaoyang Li
Control code
ocn820952410
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9781461453055
Isbn Type
(electronic bk.)
Level of compression
unknown
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)820952410
Label
Prions and diseases., Volume 1, Physiology and pathophysiology, edited by Wen-Quan Zou and Pierluigi Gambetti, (electronic resource /)
Publication
Antecedent source
unknown
Color
multicolored
Contents
  • Insoluble Cellular Prion Protein
  • Wen-Quan Zou
  • Protein Misfolding Cyclic Amplification
  • Fabio Moda, Sandra Pritzkow, Claudio Soto
  • Cofactor Involvement in Prion Propagation
  • Surachai Supattapone, Michael B. Miller
  • Prion Protein Conversion and Lipids
  • Jiyan Ma
  • New Perspectives on Prion Conversion: Introducing a Mechanism of Deformed Templating
  • Ilia V. Baskakov
  • Transmissible Spongiform Encephalopathy: From its Beginnings to Daniel Carlton Gajdusek
  • Infectious and Pathogenic Forms of PrP
  • Emiliano Biasini, David A. Harris
  • Cellular Mechanisms of Propagation and Clearance
  • Hermann M. Schatzl
  • Molecular Mechanisms Encoding Quantitative and Qualitative Traits of Prion Strains
  • Jiri G. Safar
  • Modeling the Cell Biology of Prions
  • Richard Rubenstein, Robert B. Petersen
  • Prion Strain Interference
  • Charles R. Schutt, Ronald A. Shikiya, Jason C. Bartz
  • Paul Brown
  • Introduction to Yeast and Fungal Prions
  • Reed B. Wickner
  • Yeast Prions Are Pathogenic, In-Register Parallel Amyloids
  • Reed B. Wickner, Herman K. Edskes, David A. Bateman
  • The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein
  • Glenn L. Millhauser
  • Role of Cellular Prion Protein in the Amyloid-[beta] Oligomer Pathophysiology of Alzheimer's Disease
  • Adam C. Kaufman, Stephen M. Strittmatter
  • Cellular Prion Protein and Cancers
  • Wei Xin, Man-sun Sy, Chaoyang Li
Control code
ocn820952410
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9781461453055
Isbn Type
(electronic bk.)
Level of compression
unknown
Quality assurance targets
not applicable
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)820952410

Library Locations

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