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The Resource Mitochondrial inhibitors and neurodegenerative disorders, edited by Paul R. Sanberg, Hitoo Nishino, Cesario V. Borlongan

Mitochondrial inhibitors and neurodegenerative disorders, edited by Paul R. Sanberg, Hitoo Nishino, Cesario V. Borlongan

Label
Mitochondrial inhibitors and neurodegenerative disorders
Title
Mitochondrial inhibitors and neurodegenerative disorders
Statement of responsibility
edited by Paul R. Sanberg, Hitoo Nishino, Cesario V. Borlongan
Contributor
Subject
Language
eng
Summary
In Mitochondrial Inhibitors and Neurodegenerative Disorders, respected investigators from around the world critically review what is known about the role of mitochondrial inhibitors in cell death and the onset of neurodegeneration. These distinguished researchers-many pioneers in the field-detail the symptomatology, origin, and chemistry of mitochondrial toxins, and discuss animal models of human diseases related to abnormal mitochondrial function. The book focuses on 3-nitropropionic acid (3-NP) and its ability to replicate the cellular, anatomical, and behavioral alterations seen in Huntington's disease, and demonstrates that mitochondrial inhibitors play an important role in the etiology of central nervous system disorders. In addition, recent therapeutic modalities aimed at rescuing the central nervous system from abnormal functioning by mitochondria are discussed. With its timely, in-depth review, Mitochondrial Inhibitors and Neurodegenerative Disorders offers today's advanced investigators powerful insights into how mitochondrial toxins precipitate and exacerbate neurodegenerative disorders, and details important new treatment strategies that can halt or reverse disease progression
Member of
Action
digitized
Dewey number
616.8/047
Illustrations
illustrations
Index
index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
  • Sanberg, Paul R
  • Nishino, Hitoo
  • Borlongan, Cesario V
Series statement
Contemporary neuroscience
http://library.link/vocab/subjectName
  • Nervous system
  • Nervous system
  • Mitochondrial pathology
  • Neurotoxic agents
Label
Mitochondrial inhibitors and neurodegenerative disorders, edited by Paul R. Sanberg, Hitoo Nishino, Cesario V. Borlongan
Instantiates
Publication
Antecedent source
file reproduced from original
Bibliography note
Includes bibliographical references and index
Contents
  • ""Mitochondrial Inhibitors and Neurodegenerative Disorders""; ""Foreword""; ""Preface""; ""Contents""; ""Contributors""; ""PART I. Mitochondrial Toxins: Symptomatology, Origin, and Chemistry""; ""1 Clinical Manifestations and Mechanisms of Action of Environmental Mitochondrial Toxins""; ""2 History of 3-Nitropropionic Acid: Occurrence and Role in Human and Animal Disease""; ""3 The Neurochemistry of 3-Nitropropionic Acid""; ""PART II. Mitochondrial Dysfunctions: Models of Neurodegeneration and Mechanisms of Action""; ""4 In Vitro Studies of 3-Nitropropionic Acid""
  • ""5 Cognitive and Motor Deficits Produced by Acute and Chronic Administration of 3-Nitropropionic Acid in Rats""""6 Comparative Study on 3-Nitropropionic Acid Neurotoxicity""; ""7 Mechanisms of 3-Nitropropionic Acid Neurotoxicity""; ""8 Gender-Related Difference of the Effect of 3-Nitropropionic Acid on Striatal Artery""; ""9 Variable Susceptibility to Neurotoxicity of Systemic 3-Nitropropionic Acid""; ""10 The 3-Nitropropionic Acid Model of Huntingtonâ€?s Disease: Do Alterations in the Expression of Metabolic mRNAs Predict the Development of Striatal Pathology?""
  • ""11 Mechanisms of Action of 3-Nitropropionic Acid: Dopamine Overflow and Vulnerability of the Lateral Striatal Artery""""12 Mitochondrial Inhibition and Neuronal Death in Huntingtonâ€?s Disease""; ""13 Effects of Brain Mitochondrial Metabolism, Aging, and Caloric Restriction on Membrane Lipids and Proteins: An Electron Paramagnetic Resonance Investigation""; ""14 Malonate: Profile and Mechanisms of Striatal Toxicity""; ""15 Malonic Acid and the Chronic Administration Model of Excitotoxicity""; ""16 Sodium Azide-Induced Neurotoxicity""
  • ""PART III. Treatment Interventions for Mitochondrial-Induced Neurotoxicity""""17 Neuroprotective Strategies Against Cellular Hypoxia""; ""18 Neuroprotective Effect of Perinatal Hypoxia Against 3-Nitropropionic Acid Neurotoxicity""; ""19 Neural Transplantation and Huntingtonâ€?s Disease: What Can We Learn from the 3-Nitropropionic Acid Model?""; ""20 Neuroprotective Strategies in Parkinsonâ€?s Disease and Huntingtonâ€?s Chorea: MPTP- and 3-NPA-Induced Neurodegeneration as Models""; ""Index""
Control code
ocn649757143
Dimensions
unknown
Extent
1 online resource (xvii, 313 pages)
File format
one file format
Form of item
online
Isbn
9781468498219
Note
SpringerLink
Other physical details
illustrations
Reproduction note
Electronic reproduction.
Specific material designation
remote
System control number
(OCoLC)649757143
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Label
Mitochondrial inhibitors and neurodegenerative disorders, edited by Paul R. Sanberg, Hitoo Nishino, Cesario V. Borlongan
Publication
Antecedent source
file reproduced from original
Bibliography note
Includes bibliographical references and index
Contents
  • ""Mitochondrial Inhibitors and Neurodegenerative Disorders""; ""Foreword""; ""Preface""; ""Contents""; ""Contributors""; ""PART I. Mitochondrial Toxins: Symptomatology, Origin, and Chemistry""; ""1 Clinical Manifestations and Mechanisms of Action of Environmental Mitochondrial Toxins""; ""2 History of 3-Nitropropionic Acid: Occurrence and Role in Human and Animal Disease""; ""3 The Neurochemistry of 3-Nitropropionic Acid""; ""PART II. Mitochondrial Dysfunctions: Models of Neurodegeneration and Mechanisms of Action""; ""4 In Vitro Studies of 3-Nitropropionic Acid""
  • ""5 Cognitive and Motor Deficits Produced by Acute and Chronic Administration of 3-Nitropropionic Acid in Rats""""6 Comparative Study on 3-Nitropropionic Acid Neurotoxicity""; ""7 Mechanisms of 3-Nitropropionic Acid Neurotoxicity""; ""8 Gender-Related Difference of the Effect of 3-Nitropropionic Acid on Striatal Artery""; ""9 Variable Susceptibility to Neurotoxicity of Systemic 3-Nitropropionic Acid""; ""10 The 3-Nitropropionic Acid Model of Huntingtonâ€?s Disease: Do Alterations in the Expression of Metabolic mRNAs Predict the Development of Striatal Pathology?""
  • ""11 Mechanisms of Action of 3-Nitropropionic Acid: Dopamine Overflow and Vulnerability of the Lateral Striatal Artery""""12 Mitochondrial Inhibition and Neuronal Death in Huntingtonâ€?s Disease""; ""13 Effects of Brain Mitochondrial Metabolism, Aging, and Caloric Restriction on Membrane Lipids and Proteins: An Electron Paramagnetic Resonance Investigation""; ""14 Malonate: Profile and Mechanisms of Striatal Toxicity""; ""15 Malonic Acid and the Chronic Administration Model of Excitotoxicity""; ""16 Sodium Azide-Induced Neurotoxicity""
  • ""PART III. Treatment Interventions for Mitochondrial-Induced Neurotoxicity""""17 Neuroprotective Strategies Against Cellular Hypoxia""; ""18 Neuroprotective Effect of Perinatal Hypoxia Against 3-Nitropropionic Acid Neurotoxicity""; ""19 Neural Transplantation and Huntingtonâ€?s Disease: What Can We Learn from the 3-Nitropropionic Acid Model?""; ""20 Neuroprotective Strategies in Parkinsonâ€?s Disease and Huntingtonâ€?s Chorea: MPTP- and 3-NPA-Induced Neurodegeneration as Models""; ""Index""
Control code
ocn649757143
Dimensions
unknown
Extent
1 online resource (xvii, 313 pages)
File format
one file format
Form of item
online
Isbn
9781468498219
Note
SpringerLink
Other physical details
illustrations
Reproduction note
Electronic reproduction.
Specific material designation
remote
System control number
(OCoLC)649757143
System details
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.

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