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The Resource Membrane Receptors : Methods for Purification and Characterization, edited by S. Jacobs, P. Cuatrecasas

Membrane Receptors : Methods for Purification and Characterization, edited by S. Jacobs, P. Cuatrecasas

Label
Membrane Receptors : Methods for Purification and Characterization
Title
Membrane Receptors
Title remainder
Methods for Purification and Characterization
Statement of responsibility
edited by S. Jacobs, P. Cuatrecasas
Creator
Contributor
Subject
Language
eng
Summary
Hardly a decade ago, membrane receptors were an attractive but largely unproven concept. Since that time enormous progress has been made, and we are now able to consider receptors much more concretely. Their existence has been established, their binding properties have been determined, and in some cases, they have been highly purified and their physical-chemical properties studied. It is now even possible to visualize microscopically some receptors. This progress has resulted largely from the development of highly powerful methods. These methods are the subject of this volume. Although considerably diverse, different receptors share certain common pro­ perties, and common problems are encountered in their study. Consequently, a small number of techniques are particularly useful in studying different types of receptors. Thus, it makes sense to speak about membrane receptor methodology. A very apparent problem in the study of membrane receptors is their presence in exceedingly small quantities and in a highly impure state. Therefore, very sensitive and specific techniques are required for their detection, characterization and purification. Such sensitivity and specificity is provided by the ability of receptors to bind certain ligands with very high affmity, and it is not surprising that most of the methods described in this volume depend upon this high affinity binding. The antigen-antibody interaction is of comparable sensitivity and speci­ ficity. Recently, a number of anti-receptor antibodies have been produced or found to occur spontaneously in auto-immune diseases. Undoubtedly, more will be produced in the future
Member of
http://library.link/vocab/creatorName
Jacobs, S
Dewey number
500
Index
no index present
Language note
English
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Cuatrecasas, P
Series statement
Receptors and Recognition, Series B Volume 11
http://library.link/vocab/subjectName
Science (General)
Label
Membrane Receptors : Methods for Purification and Characterization, edited by S. Jacobs, P. Cuatrecasas
Instantiates
Publication
Antecedent source
file reproduced from original
Color
mixed
Contents
1 Receptor Binding Assays -- 2 Solubilization and Characterization of Membrane Proteins -- 3 Affinity Chromatography for Membrane Receptor Purification -- 4 Affinity Labeling of Hormone Receptors and Other Ligand Binding Proteins -- 5 Immunochemical Identification and Characterization of Membrane Receptors -- 6 Quantitative Methods for Studying the Mobility and Distribution of Receptors on Viable Cells -- 7 Somatic Genetic Analysis of Hormone Action -- 8 Some Perspectives on the Hormone-Stimulated Adenylate Cyclase System
Control code
ocn851393895
Dimensions
unknown
Extent
1 online resource (xii, 240 pages)
File format
unknown
Form of item
online
Isbn
9789400958661
Level of compression
uncompressed
Note
SpringerLink
Quality assurance targets
unknown
Reformatting quality
access
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)851393895
Label
Membrane Receptors : Methods for Purification and Characterization, edited by S. Jacobs, P. Cuatrecasas
Publication
Antecedent source
file reproduced from original
Color
mixed
Contents
1 Receptor Binding Assays -- 2 Solubilization and Characterization of Membrane Proteins -- 3 Affinity Chromatography for Membrane Receptor Purification -- 4 Affinity Labeling of Hormone Receptors and Other Ligand Binding Proteins -- 5 Immunochemical Identification and Characterization of Membrane Receptors -- 6 Quantitative Methods for Studying the Mobility and Distribution of Receptors on Viable Cells -- 7 Somatic Genetic Analysis of Hormone Action -- 8 Some Perspectives on the Hormone-Stimulated Adenylate Cyclase System
Control code
ocn851393895
Dimensions
unknown
Extent
1 online resource (xii, 240 pages)
File format
unknown
Form of item
online
Isbn
9789400958661
Level of compression
uncompressed
Note
SpringerLink
Quality assurance targets
unknown
Reformatting quality
access
Sound
unknown sound
Specific material designation
remote
System control number
(OCoLC)851393895

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