Coverart for item
The Resource Clinical pharmacology : current topics and case studies, Markus Müller, editor, (electronic resource)

Clinical pharmacology : current topics and case studies, Markus Müller, editor, (electronic resource)

Label
Clinical pharmacology : current topics and case studies
Title
Clinical pharmacology
Title remainder
current topics and case studies
Statement of responsibility
Markus Müller, editor
Contributor
Subject
Language
eng
Dewey number
615/.1
Index
index present
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
Müller, Markus
http://library.link/vocab/subjectName
Pharmacology
Label
Clinical pharmacology : current topics and case studies, Markus Müller, editor, (electronic resource)
Instantiates
Publication
Note
Includes index
Bibliography note
Includes bibliographical references and index
Color
multicolored
Contents
Cover13; -- Table of Contents -- List Of Contributors -- Section 1 Introduction -- Chapter 1 The Discipline of Clinical Pharmacology -- Acknowledgement -- References -- Chapter 2 Current Issues in Drug Development -- 1 Historical Success -- 2 The Dawn of a Molecular Era, the "Druggable Genome" and Market Fragmentation -- 3 Innovation and Stagnation -- 4 The Development of Ebm Methodology -- 5 Issues in Preclinical and Clinical Drug Development -- 6 The Role of Academic Medicine -- 7 Confidence Crisis and Public Opinion -- 8 Conclusion -- Acknowledgement -- References -- Further Reading -- Chapter 3 Current Issues in Drug Regulation -- 1 The Drug Regulators' Decision-Making -- 2 Authorizing a Medicinal Product in the Eu -- 3 Regulatory Life-Cycle Management of Medicinal Products -- Disclaimer -- References -- Chapter 4 Current Issues in Drug Reimbursement -- 1 Introduction -- 2 Reimbursement Principles in General -- 3 Relative Effectiveness -- Background -- 4 Relative Effectiveness Case Study -- Data Submitted for Reimbursement in Austria -- 5 Medev -- Local Payers Vs. Global Payers -- 6 The Pharmaceutical Forum -- 7 Results -- 8 Looking Forward -- 9 In the Future -- Building a European System of Assessing Relative Effectiveness -- Acknowledgements -- Disclaimer -- References -- Section 2 Clinical Trials -- Chapter 5 Ethics in Clinical Research -- 1 Development of World-Wide Standards in Clinical Research Ethics -- 2 Research Ethics Committees Today -- Function and Composition -- 3 Research Ethics Committees -- Issues of Debate -- 4 Compensation for Committee Members -- References -- Chapter 6 Good Clinical Practice (Gcp) and Scientific Misconduct -- Good Clinical Practice -- Research Misconduct -- Acknowledgement -- References -- Chapter 7 Phase-I Studies and First-in-Human Trials -- 1 Introduction -- 2 Definition Phase I -- 3 General Considerations for Phase-I Studies, Trial Design and Study Protocol -- 4 Preclinical Development -- 5 Choice of Subjects, Study Population -- 6 Dose Finding -- 7 Route and Rate of Administration -- 8 Clinical Environment -- References -- Further Reading -- Chapter 8 Clinical Trials -- Interventional Studies -- 1 Introduction -- 2 Types of Clinical Trials -- 3 Randomization -- 4 Blinding -- 5 Different Study Designs -- 6 Study Endpoint -- 7 Interim Analyses -- References -- Chapter 9 Observational Studies -- 1 Introduction -- 2 Methodological Principles -- 3 Overview of Study Design Types -- References -- Further Reading -- Chapter 10 Pharmacokinetics I: Pk-Pd Approaches -- Antibiotic Drug Development -- 1 Pk-Pd Approach -- 2 Microdialysis for Measuring Free Drug Concentrations -- 3 Md Calibration Methods -- 4 Md and Tissue Penetration of Antibiotics -- 5 Microdialysis and Pk-Pd -- 6 Kill Curves -- 7 Experimental Settings of in Vitro Models -- 8 Conclusion -- References -- Chapter 11 Pharmacokinetics II: 14C-Labelled Microdosing in Assessing Drug Pharmacokinetics At Phase-O
Control code
ocn710812489
Dimensions
unknown
Extent
1 online resource (xxiv, 430 p.)
Form of item
online
Isbn
9783709101445
Isbn Type
(electronic bk.)
Specific material designation
remote
System control number
(OCoLC)710812489
Label
Clinical pharmacology : current topics and case studies, Markus Müller, editor, (electronic resource)
Publication
Note
Includes index
Bibliography note
Includes bibliographical references and index
Color
multicolored
Contents
Cover13; -- Table of Contents -- List Of Contributors -- Section 1 Introduction -- Chapter 1 The Discipline of Clinical Pharmacology -- Acknowledgement -- References -- Chapter 2 Current Issues in Drug Development -- 1 Historical Success -- 2 The Dawn of a Molecular Era, the "Druggable Genome" and Market Fragmentation -- 3 Innovation and Stagnation -- 4 The Development of Ebm Methodology -- 5 Issues in Preclinical and Clinical Drug Development -- 6 The Role of Academic Medicine -- 7 Confidence Crisis and Public Opinion -- 8 Conclusion -- Acknowledgement -- References -- Further Reading -- Chapter 3 Current Issues in Drug Regulation -- 1 The Drug Regulators' Decision-Making -- 2 Authorizing a Medicinal Product in the Eu -- 3 Regulatory Life-Cycle Management of Medicinal Products -- Disclaimer -- References -- Chapter 4 Current Issues in Drug Reimbursement -- 1 Introduction -- 2 Reimbursement Principles in General -- 3 Relative Effectiveness -- Background -- 4 Relative Effectiveness Case Study -- Data Submitted for Reimbursement in Austria -- 5 Medev -- Local Payers Vs. Global Payers -- 6 The Pharmaceutical Forum -- 7 Results -- 8 Looking Forward -- 9 In the Future -- Building a European System of Assessing Relative Effectiveness -- Acknowledgements -- Disclaimer -- References -- Section 2 Clinical Trials -- Chapter 5 Ethics in Clinical Research -- 1 Development of World-Wide Standards in Clinical Research Ethics -- 2 Research Ethics Committees Today -- Function and Composition -- 3 Research Ethics Committees -- Issues of Debate -- 4 Compensation for Committee Members -- References -- Chapter 6 Good Clinical Practice (Gcp) and Scientific Misconduct -- Good Clinical Practice -- Research Misconduct -- Acknowledgement -- References -- Chapter 7 Phase-I Studies and First-in-Human Trials -- 1 Introduction -- 2 Definition Phase I -- 3 General Considerations for Phase-I Studies, Trial Design and Study Protocol -- 4 Preclinical Development -- 5 Choice of Subjects, Study Population -- 6 Dose Finding -- 7 Route and Rate of Administration -- 8 Clinical Environment -- References -- Further Reading -- Chapter 8 Clinical Trials -- Interventional Studies -- 1 Introduction -- 2 Types of Clinical Trials -- 3 Randomization -- 4 Blinding -- 5 Different Study Designs -- 6 Study Endpoint -- 7 Interim Analyses -- References -- Chapter 9 Observational Studies -- 1 Introduction -- 2 Methodological Principles -- 3 Overview of Study Design Types -- References -- Further Reading -- Chapter 10 Pharmacokinetics I: Pk-Pd Approaches -- Antibiotic Drug Development -- 1 Pk-Pd Approach -- 2 Microdialysis for Measuring Free Drug Concentrations -- 3 Md Calibration Methods -- 4 Md and Tissue Penetration of Antibiotics -- 5 Microdialysis and Pk-Pd -- 6 Kill Curves -- 7 Experimental Settings of in Vitro Models -- 8 Conclusion -- References -- Chapter 11 Pharmacokinetics II: 14C-Labelled Microdosing in Assessing Drug Pharmacokinetics At Phase-O
Control code
ocn710812489
Dimensions
unknown
Extent
1 online resource (xxiv, 430 p.)
Form of item
online
Isbn
9783709101445
Isbn Type
(electronic bk.)
Specific material designation
remote
System control number
(OCoLC)710812489

Library Locations

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