Coverart for item
The Resource Biotransformation and metabolite elucidation of xenobiotics, edited by Ala F. Nassar, (electronic resource)

Biotransformation and metabolite elucidation of xenobiotics, edited by Ala F. Nassar, (electronic resource)

Label
Biotransformation and metabolite elucidation of xenobiotics
Title
Biotransformation and metabolite elucidation of xenobiotics
Statement of responsibility
edited by Ala F. Nassar
Contributor
Subject
Language
eng
Summary
The goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity. The book consists of 8 chapters; it first provides an introduction on biotransformation of xenobiotics, and then presents modern approaches and strategies for dealing with metabolite characterization, using tools
Dewey number
615.9
Index
index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
http://library.link/vocab/relatedWorkOrContributorName
  • Nassar, Ala F
  • Wiley InterScience (Online service)
http://library.link/vocab/subjectName
  • Xenobiotics
  • Metabolites
  • Biotransformation (Metabolism)
  • Identification
  • Metabolism
  • Metabolites
  • Xenobiotics
  • Science
  • Medicine
  • Natural history
  • Xenobiotics
  • Xenobiotics
  • Biotransformation
  • Drug Discovery
Label
Biotransformation and metabolite elucidation of xenobiotics, edited by Ala F. Nassar, (electronic resource)
Instantiates
Publication
Bibliography note
Includes bibliographical references and index
Color
multicolored
Contents
  • Frontmatter -- Human Biotransformation / Andrew Parkinson, Brian W Ogilvie, Brandy L Paris, Tiffini N Hensley, Greg J Loewen -- Analytical Tools and Approaches for Metabolite Identification in Drug Metabolism / Yongmei Li -- Tools of Choice for Accelerating Metabolite Identification: Mass Spectrometry Technology Drives Metabolite Identification Studies Forward / Ala F Nassar -- Improving Drug Design: Considerations for the Structural Modification Process / Ala F Nassar -- Case Study: The Unanticipated Loss of N from Novel DNA Alkylating Agent Laromustine by Collision-Induced Dissociation: Novel Rearrangements / Ala F Nassar, Jing Du, David Roberts, Kevin Lin, Mike Belcourt, Ivan King, Tukiet T Lam -- Case Study: Identification of Metabolite/Decomposition Products of the Novel DNA Alkylating Agent Laromustine / Ala F Nassar, Jing Du, David Roberts, Kevin Lin, Mike Belcourt, Ivan King, Tukiet T Lam -- Strategies for the Detection of Reactive Intermediates in Drug Discovery and Development / Mark P Grillo -- Safety Testing of Drug Metabolites: Mist Guidance Impact on the Practice of Industrial Drug Metabolism / J Greg Slatter -- Index
  • Human biotransformation / Andrew Parkinson -- Analytical tools and approaches for metabolite identification in drug metabolism / Yongmei Li -- Tools of choice for accelerating metabolite identification : mass spec technology drives metabolite identification studies forward / Ala Nassar -- Improving drug design : considerations for the structural modification process / Ala Nassar -- Case study : the unanticipated loss of N2 from novel dna alkylating agent laromustine by collision-induced dissociation : novel rearrangements / Ala Nassar, Tukiet T. Lam -- Case study : identification of in vitro metabolite/decomposition products of the novel DNA alkylating agent laromustine / Ala Nassar, TuKiet T. Lam -- Strategies for the detection of reactive intermediates in drug discovery and development / Mark P. Grillo -- Safety testing of drug metabolites : MIST guidance impact on the practice of industrial drug metabolism / J. Greg Slatter
Control code
ocn669165475
Dimensions
unknown
Extent
1 online resource (xi, 328 pages)
Form of item
online
Isbn
9780470890387
Note
Wiley
Other control number
10.1002/9780470890387
Specific material designation
remote
System control number
(OCoLC)669165475
Label
Biotransformation and metabolite elucidation of xenobiotics, edited by Ala F. Nassar, (electronic resource)
Publication
Bibliography note
Includes bibliographical references and index
Color
multicolored
Contents
  • Frontmatter -- Human Biotransformation / Andrew Parkinson, Brian W Ogilvie, Brandy L Paris, Tiffini N Hensley, Greg J Loewen -- Analytical Tools and Approaches for Metabolite Identification in Drug Metabolism / Yongmei Li -- Tools of Choice for Accelerating Metabolite Identification: Mass Spectrometry Technology Drives Metabolite Identification Studies Forward / Ala F Nassar -- Improving Drug Design: Considerations for the Structural Modification Process / Ala F Nassar -- Case Study: The Unanticipated Loss of N from Novel DNA Alkylating Agent Laromustine by Collision-Induced Dissociation: Novel Rearrangements / Ala F Nassar, Jing Du, David Roberts, Kevin Lin, Mike Belcourt, Ivan King, Tukiet T Lam -- Case Study: Identification of Metabolite/Decomposition Products of the Novel DNA Alkylating Agent Laromustine / Ala F Nassar, Jing Du, David Roberts, Kevin Lin, Mike Belcourt, Ivan King, Tukiet T Lam -- Strategies for the Detection of Reactive Intermediates in Drug Discovery and Development / Mark P Grillo -- Safety Testing of Drug Metabolites: Mist Guidance Impact on the Practice of Industrial Drug Metabolism / J Greg Slatter -- Index
  • Human biotransformation / Andrew Parkinson -- Analytical tools and approaches for metabolite identification in drug metabolism / Yongmei Li -- Tools of choice for accelerating metabolite identification : mass spec technology drives metabolite identification studies forward / Ala Nassar -- Improving drug design : considerations for the structural modification process / Ala Nassar -- Case study : the unanticipated loss of N2 from novel dna alkylating agent laromustine by collision-induced dissociation : novel rearrangements / Ala Nassar, Tukiet T. Lam -- Case study : identification of in vitro metabolite/decomposition products of the novel DNA alkylating agent laromustine / Ala Nassar, TuKiet T. Lam -- Strategies for the detection of reactive intermediates in drug discovery and development / Mark P. Grillo -- Safety testing of drug metabolites : MIST guidance impact on the practice of industrial drug metabolism / J. Greg Slatter
Control code
ocn669165475
Dimensions
unknown
Extent
1 online resource (xi, 328 pages)
Form of item
online
Isbn
9780470890387
Note
Wiley
Other control number
10.1002/9780470890387
Specific material designation
remote
System control number
(OCoLC)669165475

Library Locations

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